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High efficacy of therapeutic equine hyperimmune antibodies against SARS CoV-2 variants of concern (preprint)
Andres Moreira-Soto; Mauricio Arguedas; Hebleen Brenes; Willem Buján; Eugenia Corrales-Aguilar; Cecilia Díaz; Ann Echeverri; Marietta Flores-Díaz; Aarón Gómez; Andrés Hernández; María Herrera; Guillermo León; Román Macaya; Arne Khüne; Jose Arturo Molina-Mora; Javier Mora; Alfredo Sanabria; Andrés Sánchez; Laura Sánchez; Álvaro Segura; Eduardo Segura; Daniela Solano; Claudio Soto; Jennifer L. Stynoski; Mariangela Vargas; Mauren Villalta; Chantal Reusken; Chistian Drosten; José María Gutiérrez; Alberto Alape-Girón; Jan Felix Drexler.
biorxiv; 2021.
Preprint in English | bioRxiv | ID: ppzbmed-10.1101.2021.06.12.448080

ABSTRACT

SARS-CoV-2 variants of concern (VoC) show reduced neutralization by vaccine-induced and therapeutic monoclonal antibodies. We tested therapeutic equine polyclonal antibodies (pAbs) against four VoC (alpha, beta, epsilon and gamma). We show that equine pAbs efficiently neutralize VoC, suggesting they are an effective, broad coverage, low-cost and a scalable COVID-19 treatment.


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COVID-19
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